The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 23 kDa (predicted molecular weight: 26 kDa).
功能Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
组织特异性Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
序列相似性Contains 1 C-type lectin domain.
翻译后修饰Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding.