概述

  • 产品名称Anti-CLEC12A抗体
    参阅全部 CLEC12A 一抗
  • 描述
    兔多克隆抗体to CLEC12A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, between amino acids 185-214 from the Central region of Human CLEC12A (NP_612210.4, NP_963917.2).

  • 阳性对照
    • ZR-75-1 cell line lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab107494 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab107494 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 31 kDa.

靶标

  • 功能Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
  • 组织特异性Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
  • 序列相似性Contains 1 C-type lectin domain.
  • 结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • 翻译后修饰Highly N-glycosylated. Glycosylation varies between cell types.
  • 细胞定位Cell membrane. Ligand binding leads to internalization.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C-type lectin domain family 12 member A antibody
    • C-type lectin-like molecule 1 antibody
    • CL12A_HUMAN antibody
    • CLEC12A antibody
    • CLL-1 antibody
    • DCAL-2 antibody
    • Dendritic cell-associated lectin 2 antibody
    • MICL antibody
    • Myeloid inhibitory C-type lectin-like receptor antibody
    see all

Anti-CLEC12A antibody 图像

  • Anti-CLEC12A antibody (ab107494) at 1/100 dilution + ZR-75-1 cell line lysate at 35 µg

    Predicted band size : 31 kDa

Anti-CLEC12A antibody (ab107494)参考文献

ab107494 has not yet been referenced specifically in any publications.

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