功能Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
组织特异性Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
序列相似性Contains 1 C-type lectin domain.
结构域Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
翻译后修饰Highly N-glycosylated. Glycosylation varies between cell types.
细胞定位Cell membrane. Ligand binding leads to internalization.