Anti-cleaved RB抗体[172C1094] (ab13905)

概述

  • 产品名称Anti-cleaved RB抗体[172C1094]
  • 描述
    小鼠单克隆抗体[172C1094] to cleaved RB
  • 特异性Ab13905 recognises the 68 kD fragment of cleaved RB.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to region of the caspase 3 induced cleavage site of human RB was used as immunogen.

  • 阳性对照
    • Whole cell lysate from camptothecin induced apoptotic HL60 cells.

性能

应用

Our Abpromise guarantee covers the use of ab13905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 µg/ml. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).

靶标

  • 相关性Retinoblastoma gene product (RB) is a tumor suppressor protein and acts as cell cycle regulator. Recently, RB has been shown to play a role in apoptosis. During apoptosis, RB is subjected to cleavage by caspase 3 like protease. Caspase 3 cleaves RB into 48 and 68kDa fragments. Cleavage of RB would make it functionally inactive, causing release of E2F 1. The E2F 1 then may promote apoptosis.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • OSRC antibody
    • P105 RB antibody
    • PP110 antibody
    • RB1 antibody
    • Retinoblastoma 1 antibody
    • Retinoblastoma associated protein antibody
    see all

Anti-cleaved RB antibody [172C1094] 图像



  • Predicted band size : 68 kDa


    Western blot analysis: HL60 cells were treated for with camptothecin for 24 hours. Harvested cells were lysed and resolved by SDS-PAGE and transferred onto membrane. The membrane was stained with ab13905 and immunoreactivity was detected by chemiluminescense.

Anti-cleaved RB antibody [172C1094] (ab13905)参考文献

ab13905 has not yet been referenced specifically in any publications.

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