Anti-cleaved IKB alpha抗体(ab13904)

概述

  • 产品名称Anti-cleaved IKB alpha抗体
  • 描述
    小鼠单克隆抗体to cleaved IKB alpha
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to the caspase-3 mediated cleavage site.

  • 阳性对照
    • Tested with Jurkat cell lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab13904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 35 kDa.

靶标

  • 相关性NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NFkB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. Recent studies have shown that IkB alpha can be cleaved by caspases during apoptosis to produce an amino-terminal truncated IkB alpha (DNIkB alpha). The DNIkB alpha is resistant to degradation in response to inducers of NFkB and act as dominant inhibitory molecule that suppresses NFkB activity during apoptosis.
  • 数据库链接
  • 别名
    • IKBA antibody
    • MAD3 antibody
    • NFKBI antibody
    • NFKBIA antibody
    • Nuclear factor of kappa light chain gene enhancer in B-cells antibody
    see all

Anti-cleaved IKB alpha antibody 图像

  • Detection of cleaved IkB alpha in Jurkat cell lysates. Lane A. untreated cell lysate. Lane B. Jurkat cells treated with anti-Fas antibody for 30 mins.

Anti-cleaved IKB alpha antibody (ab13904)参考文献

ab13904 has not yet been referenced specifically in any publications.

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