概述

  • 产品名称Anti-CLCNKB抗体
    参阅全部 CLCNKB 一抗
  • 描述
    兔多克隆抗体to CLCNKB
  • 经测试应用适用于: IHC-P, WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Human
  • 免疫原

    Synthetic peptide derived from the C terminal domain of Mouse CLCNKB

性能

应用

Our Abpromise guarantee covers the use of ab66460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 75 kDa.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
  • 组织特异性Expressed predominantly in the kidney.
  • 疾病相关Defects in CLCNKB are the cause of Bartter syndrome type 3 (BS3) [MIM:607364]; also known as classic Bartter syndrome. It is an autosomal recessive form of often severe intravascular volume depletion due to renal salt-wasting associated with low blood pressure, hypokalemic alkalosis, hypercalciuria, and normal serum magnesium levels.
    Defects in CLCNKB are a cause of Bartter syndrome type 4B (BS4B) [MIM:613090]. A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness.
  • 序列相似性Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
    Contains 2 CBS domains.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Bartter syndrome type 3 antibody
    • Chloride channel Kb antibody
    • Chloride channel kidney B antibody
    • Chloride channel protein ClC-Kb antibody
    • Chloride channel voltage sensitive Kb antibody
    • ClC K2 antibody
    • ClC-K2 antibody
    • ClCK2 antibody
    • CLCKB antibody
    • CLCKB_HUMAN antibody
    • CLCNKB antibody
    • hClC Kb antibody
    • hClCKb antibody
    • MGC24087 antibody
    • OTTHUMP00000011120 antibody
    • OTTHUMP00000011121 antibody
    • RP11 5P18.8 antibody
    see all

Anti-CLCNKB antibody (ab66460)参考文献

ab66460 has not yet been referenced specifically in any publications.

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