功能Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
组织特异性Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney.
序列相似性Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. Contains 2 CBS domains.
翻译后修饰N-glycosylated on several asparagine residues.
细胞定位Endosome membrane. Detected in detergent-resistant lipid rafts.