概述

  • 产品名称Anti-CLCN1抗体
    参阅全部 CLCN1 一抗
  • 描述
    兔多克隆抗体to CLCN1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within C-terminal amino acids 771-820 (SSIFQRLLHC LLGKAHSTKK KITQDSTDLV DNMSPEEIEA WEREQLSQPV) of Rat CLCN1 (NP_037279).

  • 阳性对照
    • Rat brain lysate.

性能

应用

Our Abpromise guarantee covers the use of ab110985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 110 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
  • 组织特异性Predominantly expressed in skeletal muscles.
  • 疾病相关Defects in CLCN1 are the cause of Thomsen disease (THD) [MIM:160800]; also known as autosomal dominant myotonia congenita (MCD). THD is characterized by skeletal muscle stiffness (delayed relaxation), due to membrane hyperexcitability. A variant form of Thomsen disease is myotonia levior that is characterized by milder symptoms, later onset and absence of muscle hypo- and hypertrophy.
    Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR) [MIM:255700]; also known as Becker disease.
  • 序列相似性Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.
    Contains 2 CBS domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Chloride channel protein 1 antibody
    • Chloride channel protein antibody
    • Chloride channel protein skeletal muscle antibody
    • CIC 1 antibody
    • CIC1 antibody
    • ClC-1 antibody
    • CLC1 antibody
    • Clcn1 antibody
    • CLCN1_HUMAN antibody
    • MGC138361 antibody
    • MGC142055 antibody
    • skeletal muscle antibody
    see all

Anti-CLCN1 antibody 图像



  • Predicted band size : 110 kDa
    Western blot analysis of Mouse muscle membrane fragment labeling CLCN1 with ab110985 at 1:1000. A HRP-conjugated anti-rabbit IgG (1:2000) was used as the secondary antibody. Lane 1 - Mouse muscle membrane fraction. Lane 3 - Mouse brain membrane fraction. Lane 5 - Mouse muscle cytosolic fraction. Lane 6 - Mouse brain cytosolic fraction. Lane 2 and 4 empty.
  • Anti-CLCN1 antibody (ab110985) at 1 µg/ml + Rat brain lysate at 10 µg

    Predicted band size : 110 kDa

Anti-CLCN1 antibody (ab110985)参考文献

ab110985 has not yet been referenced specifically in any publications.

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