概述

  • 产品名称Anti-CLCA1抗体
    参阅全部 CLCA1 一抗
  • 描述
    小鼠单克隆抗体to CLCA1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment: ALGGVNAARR RVIPQQSGAL YIPGWIENDE IQWNPPRPEI NKDDVQHKQV CFSRTSSGGS FVASDVPNAP IPDLFPPGQI TDLKAEIHGG SLINLTWTAP , corresponding to amino acids 677-777 of Human CLCA1

性能

应用

Our Abpromise guarantee covers the use of ab54662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
    • 组织特异性Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic andhealthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
    • 序列相似性Belongs to the CLCR family.
      Contains 1 VWFA domain.
    • 翻译后修饰Glycosylated.
      The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins.
    • 细胞定位Secreted > extracellular space. Cell membrane. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CaCC antibody
      • CaCC-1 antibody
      • CACC1 antibody
      • Calcium dependent chloride channel 1 antibody
      • Calcium-activated chloride channel family member 1 antibody
      • Calcium-activated chloride channel protein 1 antibody
      • Calcium-activated chloride channel regulator 1 antibody
      • Chloride channel calcium activated family member 1 antibody
      • Chloride channel regulator 1 antibody
      • CLCA family member 1 chloride channel regulator antibody
      • CLCA1 antibody
      • CLCA1_HUMAN antibody
      • CLCRG1 antibody
      • GOB5 antibody
      • hCaCC-1 antibody
      • hCLCA1 antibody
      see all

    Anti-CLCA1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54662 CLCA1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-CLCA1 antibody (ab54662)参考文献

    ab54662 has not yet been referenced specifically in any publications.

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