Anti-Claudin 7抗体, prediluted (ab27488)

概述

  • 产品名称Anti-Claudin 7抗体, prediluted
    参阅全部 Claudin 7 一抗
  • 描述
    兔多克隆抗体to Claudin 7, prediluted
  • 特异性ab27488 recognises claudin 7.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    A synthetic peptide from C-terminus of human claudin 7 protein

  • 阳性对照
    • Human colon carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab27488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: use neat for 10 min at room temperature. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. In particular, boil tissue sections in 10mM citrate buffer pH 6.0 for 10 min and then cool at room temperature for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Plays a major role in tight junction-specific obliteration of the intercellular space.
    • 组织特异性Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
    • 序列相似性Belongs to the claudin family.
    • 翻译后修饰Phosphorylated.
    • 细胞定位Cell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CEPTR L2 antibody
      • CEPTRL 2 antibody
      • CEPTRL2 antibody
      • Claudin 1 antibody
      • Claudin 9 antibody
      • Claudin-7 antibody
      • Claudin1 antibody
      • Claudin7 antibody
      • Claudin9 antibody
      • CLD7_HUMAN antibody
      • CLDN 7 antibody
      • CLDN-7 antibody
      • CLDN7 antibody
      • Clostridium perfringens enterotoxin receptor like 2 antibody
      • CPETR L2 antibody
      • CPETRL 2 antibody
      • CPETRL2 antibody
      • Hs.84359 antibody
      see all

    Anti-Claudin 7 antibody, prediluted 图像

    • Paraffin embedded formalin fixed human colon carcinoma tissue section stained with anti claudin 7 (ab27488).

    Anti-Claudin 7 antibody, prediluted (ab27488)参考文献

    ab27488 has not yet been referenced specifically in any publications.

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