功能Plays a major role in tight junction-specific obliteration of the intercellular space.
组织特异性Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
序列相似性Belongs to the claudin family.
细胞定位Cell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
Immunohistochemical analysis of Claudin 7 in paraffin embedded human prostate carcinoma tissue, using ab79481 at a 1/100 dilution in the absence (left image) and presence (right image) of the immunizing peptide.
Anti-Claudin 7 antibody (ab79481)参考文献
has not yet been referenced specifically in any publications.