概述

  • 产品名称
    Anti-Claudin 14抗体
    参阅全部 Claudin 14 一抗
  • 描述
    山羊多克隆抗体to Claudin 14
  • 经测试应用
    适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken
  • 免疫原

    Synthetic peptide:

    SATHSGYRLNDYV

    conjugated to KLH, corresponding to C terminal amino acids 227-239 of Human Claudin 14 (NP_036262.1).

  • 阳性对照
    • Human pancreas tissue; Human liver lysate.

性能

应用

Our Abpromise guarantee covers the use of ab115868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 26 kDa.
ELISA 1/128000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 组织特异性
    Liver, kidney. Also found in ear.
  • 疾病相关
    Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29) [MIM:605608]. DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • 序列相似性
    Belongs to the claudin family.
  • 细胞定位
    Cell junction > tight junction. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI851731 antibody
    • Claudin 14 antibody
    • Claudin-14 antibody
    • CLD14_HUMAN antibody
    • CLDN 14 antibody
    • CLDN14 antibody
    • DFNB 29 antibody
    • DFNB29 antibody
    • Human CLDN14 gene antibody
    • MGC109472 antibody
    • OTTHUMP00000109046 antibody
    • OTTHUMP00000109049 antibody
    • OTTMUSP00000021531 antibody
    • UNQ777/PRO1571 antibody
    see all

图片

  • ab115868, at 5 µg/ml, staining Claudin 14 in Formalin-fixed, Paraffin-embedded Human pancreas tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-Claudin 14 antibody (ab115868) at 1 µg/ml + Human liver lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 26 kDa

文献

This product has been referenced in:
  • Gao M  et al. The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues. Diagn Pathol 8:205 (2013). Human . Read more (PubMed: 24325792) »

See 1 Publication for this product

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