重组
RabMAb

Anti-Claudin 1抗体[SP128] (ab115783)

概述

  • 产品名称
    Anti-Claudin 1抗体[SP128]
    参阅全部 Claudin 1 一抗
  • 描述
    兔单克隆抗体[SP128] to Claudin 1
  • 经测试应用
    适用于: IHC-P, Flow Cytmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Pig
  • 免疫原

    Synthetic peptide corresponding to C-terminus of Human Claudin 1.

  • 阳性对照
    • Human liver carcinoma tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    pH: 7.60
    Preservative: 0.1% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 纯化说明
    Purified by Protein A/G
  • 克隆
    单克隆
  • 克隆编号
    SP128
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/200. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Flow Cyt 1/100. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

靶标

  • 功能
    Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
    (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes (PubMed:17325668). Acts as a receptor for dengue virus (PubMed:24074594).
  • 组织特异性
    Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • 疾病相关
    Ichthyosis-sclerosing cholangitis neonatal syndrome
  • 序列相似性
    Belongs to the claudin family.
  • 细胞定位
    Cell junction, tight junction. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Claudin-1 antibody
    • Claudin1 antibody
    • CLD 1 antibody
    • CLD1 antibody
    • CLD1_HUMAN antibody
    • CLDN 1 antibody
    • Cldn1 antibody
    • ILVASC antibody
    • SEMP 1 antibody
    • SEMP1 antibody
    • Senescence associated epithelial membrane protein 1 antibody
    • Senescence associated epithelial membrane protein antibody
    • Senescence-associated epithelial membrane protein antibody
    see all

图片

  • Flow cytometric analysis of rabbit anti-Claudin 1 (SP128) antibody ab115783 (1/100) in HepG2 cells(green) compared to negative control of rabbit IgG (blue).

  • Staining of Human Claudin 1 in a Formalin/PFA-fixed paraffin-embedded section of Human Liver Carcinoma using ab115783 at a dilution of 1/200.

文献

ab115783 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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