Anti-Claudin 1抗体, prediluted (ab15099)


  • 产品名称Anti-Claudin 1抗体, prediluted
    参阅全部 Claudin 1 一抗
  • 描述
    兔多克隆抗体to Claudin 1, prediluted
  • 经测试应用适用于: WB, ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse, Dog, Monkey
  • 免疫原

    Synthetic peptide (Human) (C terminal).

  • 阳性对照
    • Tested with skin or breast carcinoma cells.


  • 形式Prediluted
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 1% BSA, 50mM Tris, pH 7.6
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab15099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Use neat.
ICC/IF 1/200. PubMed: 17583679
IHC-P Use at an assay dependent concentration. Ready to use. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.


  • 功能Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
    (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes (PubMed:17325668). Acts as a receptor for dengue virus (PubMed:24074594).
  • 组织特异性Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • 疾病相关Ichthyosis-sclerosing cholangitis neonatal syndrome
  • 序列相似性Belongs to the claudin family.
  • 细胞定位Cell junction, tight junction. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Claudin-1 antibody
    • Claudin1 antibody
    • CLD 1 antibody
    • CLD1 antibody
    • CLD1_HUMAN antibody
    • CLDN 1 antibody
    • Cldn1 antibody
    • ILVASC antibody
    • SEMP 1 antibody
    • SEMP1 antibody
    • Senescence associated epithelial membrane protein 1 antibody
    • Senescence associated epithelial membrane protein antibody
    • Senescence-associated epithelial membrane protein antibody
    see all

Anti-Claudin 1 antibody, prediluted 图像

  • Human skin stained with ab15099.
  • Anti-Claudin 1 antibody (ab15098) at 1/25 dilution + HeLa cell lysate

    Observed band size : 19 kDa (why is the actual band size different from the predicted?)

Anti-Claudin 1 antibody, prediluted (ab15099)参考文献

This product has been referenced in:
  • Lim JC  et al. Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells. Brain Res 1159:67-76 (2007). ICC/IF ; Rat . Read more (PubMed: 17583679) »

See 1 Publication for this product

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The concentration is 1.85 ug/ml for lot GR64050.  Please do not hesitate to contact me with any additional questions.