Anti-Clathrin heavy chain抗体[2Q2166] (ab14401)

概述

  • 产品名称Anti-Clathrin heavy chain抗体[2Q2166]
    参阅全部 Clathrin heavy chain 一抗
  • 描述
    小鼠单克隆抗体[2Q2166] to Clathrin heavy chain
  • 特异性Recognizes the clathrin heavy chain from a diverse range of species. In nervous tissue it crossreacts with another coated vesicle polypeptide of 190kD which is not present in isolated clathrin triskelions. In some epithelial cells of certain species the antibody may crossreact with a cytokeratin component. It detects coated vesicles from different organs and tissues (e.g. brain, ovary, mammary gland).
  • 经测试应用适用于: IHC-Fr, WBmore details
  • 种属反应性
    Reacts with a wide range of species.
  • 免疫原

    Coated vesicles (clathrin) of bovine brain

性能

应用

Our Abpromise guarantee covers the use of ab14401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent dilution.
WB Use at an assay dependent concentration. Predicted molecular weight: 192 kDa.

靶标

  • 功能Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
  • 序列相似性Belongs to the clathrin heavy chain family.
  • 细胞定位Cytoplasmic vesicle membrane. Membrane > coated pit. Melanosome. Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 别名
    • CHC17 antibody
    • Clathrin heavy chain antibody
    • Clathrin heavy chain 1 antibody
    • Clathrin heavy chain 2 antibody
    • Clathrin heavy chain like 1 antibody
    • Clathrin heavy chain on chromosome 17 antibody
    • Clathrin heavy polypeptide antibody
    • CLH 17 antibody
    • CLH 22 antibody
    • CLH-17 antibody
    • CLH1_HUMAN antibody
    • CLH17 antibody
    • CLH22 antibody
    • CLTC antibody
    • CLTCL antibody
    • CLTCL1 antibody
    • CLTCL2 antibody
    • CLTD antibody
    • Hc antibody
    • KIAA0034 antibody
    see all

Anti-Clathrin heavy chain antibody [2Q2166] (ab14401)参考文献

This product has been referenced in:
  • Sens-Abuázar C  et al. Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast. Transl Oncol 5:113-23 (2012). WB, IHC-Fr ; Human . Read more (PubMed: 22496928) »
  • Marx C  et al. ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination. Cancer Res 70:3709-17 (2010). WB ; Human . Read more (PubMed: 20406983) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"