概述

  • 产品名称Anti-CKAP2抗体
    参阅全部 CKAP2 一抗
  • 描述
    兔多克隆抗体to CKAP2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Horse, Guinea pig, Cat
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 349-398 (GKAIVDSRSA QPKETSEERK ARLSEWKAGK GRVLKRPPNS VVTQHEPAGQ) of Human CKAP2 (NP_001091995).

  • 阳性对照
    • Human fetal lung lysate

性能

应用

Our Abpromise guarantee covers the use of ab116460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 77 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.
  • 组织特异性Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
  • 序列相似性Belongs to the CKAP2 family.
  • 发展阶段Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C).
  • 细胞定位Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI461656 antibody
    • AW228814 antibody
    • CKAP 2 antibody
    • Ckap2 antibody
    • CKAP2_HUMAN antibody
    • CTCL tumor antigen se20 10 antibody
    • CTCL tumor antigen se20-10 antibody
    • Cytoskeleton associated protein 2 antibody
    • Cytoskeleton-associated protein 2 antibody
    • DKFZp686L1238 antibody
    • FLJ10749 antibody
    • LB1 antibody
    • se20 10 antibody
    • TMAP antibody
    • Tumor and microtubule associated protein antibody
    • Tumor associated microtubule associated protein antibody
    • Tumor- and microtubule-associated protein antibody
    see all

Anti-CKAP2 antibody 图像

  • Anti-CKAP2 antibody (ab116460) at 1 µg/ml + Human fetal lung lysate at 10 µg

    Predicted band size : 77 kDa

Anti-CKAP2 antibody (ab116460)参考文献

ab116460 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116460.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"