Anti-CIT抗体(ab110897)
Key features and details
- Rabbit polyclonal to CIT
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CIT抗体
参阅全部 CIT 一抗 -
描述
兔多克隆抗体to CIT -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide corresponding to Human CIT aa 1000-1100 (internal sequence).
Database link: O14578 -
阳性对照
- Human brain tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS (without Mg2+ and Ca2+) -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab110897 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110897于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. -
序列相似性
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 CNH domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 protein kinase domain. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 11113 Human
- Entrez Gene: 12704 Mouse
- Omim: 605629 Human
- SwissProt: O14578 Human
- SwissProt: P49025 Mouse
- Unigene: 119594 Human
- Unigene: 426282 Mouse
- Unigene: 8321 Mouse
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别名
- CIT antibody
- Citron (rho interacting serine/threonine kinase 21) antibody
- Citron antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab110897 被引用在 3 文献中.
- Liu Z et al. Novel circRNA_0071196/miRNA-19b-3p/CIT axis is associated with proliferation and migration of bladder cancer. Int J Oncol 57:767-779 (2020). PubMed: 32705161
- Zhang HQ et al. Low expression of citron kinase is associated with poor patient outcomes in hepatocellular carcinoma. Transl Cancer Res 9:2416-2423 (2020). PubMed: 35117601
- Wu Z et al. Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget 8:71954-71964 (2017). PubMed: 29069760