概述

  • 产品名称Anti-CISD2抗体
    参阅全部 CISD2 一抗
  • 描述
    兔多克隆抗体to CISD2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide: VLESVARIVK VQLPAYLKRL PVPESITGFA RLTVSEWLRL LPFLGVLALL , corresponding to N terminal amino acids 1-50 of Human CISD2 (NP_001008389)

  • 阳性对照
    • Transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab80509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 15 kDa (predicted molecular weight: 15 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
  • 组织特异性Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.
  • 疾病相关Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2) [MIM:604928]. A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal ulceration. Diabetes insipidus may be absent.
  • 序列相似性Belongs to the CISD protein family. CISD2 subfamily.
  • 细胞定位Endoplasmic reticulum membrane. Mitochondrion outer membrane. According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1500009M05Rik antibody
    • 1500026J14Rik antibody
    • 1500031D15Rik antibody
    • AI848398 antibody
    • B630006A20Rik antibody
    • CDGSH iron sulfur domain 2 antibody
    • CDGSH iron-sulfur domain-containing protein 2 antibody
    • CDGSH type domain 2 antibody
    • CISD2 antibody
    • CISD2_HUMAN antibody
    • Endoplasmic reticulum intermembrane small protein antibody
    • ERIS antibody
    • Miner1 antibody
    • MitoNEET related 1 antibody
    • MitoNEET-related 1 protein antibody
    • NAF-1 antibody
    • Noxp70 antibody
    • Nutrient deprivation autophagy factor 1 antibody
    • Nutrient-deprivation autophagy factor-1 antibody
    • OTTHUMP00000219576 antibody
    • RGD1566242 antibody
    • WFS2 antibody
    • Zcd2 antibody
    • Zinc finger antibody
    • Zinc finger, CDGSH type domain 2 antibody
    see all

Anti-CISD2 antibody 图像

  • Anti-CISD2 antibody (ab80509) at 1 µg/ml + Transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 15 kDa
    Observed band size : 15 kDa

Anti-CISD2 antibody (ab80509)参考文献

ab80509 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab80509.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"