概述

  • 产品名称Ciproxifan maleate
  • 描述
    Potent prototypic H3 inverse agonist / antagonist
  • 生物学描述Potent prototypic H3 inverse agonist / antagonist (pKi = 7.2 nM). Improves attention and wakefulness in vivo. Additionally improves memory function.
  • 纯度> 98%

性能

  • 化学名称Cyclopropyl [4-[3-(1H-imidazol-4-yl)propoxy]phenyl]methanone maleate
  • 分子量386.40
  • 化学结构Chemical Structure
  • 分子式C16H18N2O2.C4H4O4
  • CAS编号184025-19-2
  • 存放说明Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESO=C(O)/C=C\C(=O)O.O=C(C1CC1)c3ccc(OCCCc2cncn2)cc3
  • 来源

    Synthetic

  • 研究领域

    Ciproxifan maleate (ab120779)参考文献

    This product has been referenced in:
    • Bardgett ME  et al. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem 95:64-72 (2011). Read more (PubMed: 21073971) »
    • Fox GB  et al. Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization. J Pharmacol Exp Ther 305:897-908 (2003). Read more (PubMed: 12606600) »
    • Ligneau X  et al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther 287:658-66 (1998). Read more (PubMed: 9808693) »
    • Felberg NT  et al. CEA family syndrome. Abnormal carcinoembryonic antigen (CEA) levels in asymptomatic retinoblastoma family members. Cancer 37:1397-402 (1976). Read more (PubMed: 1260660) »

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