Anti-Cip4抗体[EPR1965] (ab108313)


  • 产品名称Anti-Cip4抗体[EPR1965]
    参阅全部 Cip4 一抗
  • 描述
    兔单克隆抗体[EPR1965] to Cip4
  • 特异性Recent WB re-tests performed by our lab suggest to use a higher dilution for mouse samples. The tested dilutions were 1:500 and 1:2000, were the signal detected was very strong. Human and rat samples worked fine in these dilutions.
  • 经测试应用适用于: WB, IHC-Pmore details
    不适用于: Flow Cyt,ICC or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human Cip4.

  • 阳性对照
    • JAR, HepG2, TF1, and HeLa cell lysates; Human stomach tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab108313 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 68 kDa.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IP.
  • 靶标

    • 功能Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
    • 组织特异性Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
    • 序列相似性Belongs to the FNBP1 family.
      Contains 1 FCH domain.
      Contains 1 REM (Hr1) repeat.
      Contains 1 SH3 domain.
    • 翻译后修饰Tyrosine phosphorylated. Also phosphorylated by PKA.
    • 细胞定位Cytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cdc42 interacting protein 4 antibody
      • Cdc42 interaction protein 4 long isoform antibody
      • Cdc42-interacting protein 4 antibody
      • CG11341 antibody
      • CG15015 PA antibody
      • Cip 4 antibody
      • CIP4 antibody
      • CIP4_HUMAN antibody
      • DCIP4 antibody
      • hSTP antibody
      • Protein Felic antibody
      • Salt tolerant protein antibody
      • Salt tolerator antibody
      • STOT antibody
      • STP antibody
      • Thyroid hormone receptor interactor 10 antibody
      • Thyroid receptor interacting protein 10 antibody
      • Thyroid receptor-interacting protein 10 antibody
      • TR-interacting protein 10 antibody
      • TRIP 10 antibody
      • TRIP-10 antibody
      • trip10 antibody
      • Truncated Cdc42 interaction protein 4 antibody
      see all

    Anti-Cip4 antibody [EPR1965] 图像

    • All lanes : Anti-Cip4 antibody [EPR1965] (ab108313) at 1/1000 dilution

      Lane 1 : JAR cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : TF1 cell lysate
      Lane 4 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 68 kDa
    • ab108313 at 1/100 dilution staining Cip4 in paraffin embedded Human stomach tissue.

    Anti-Cip4 antibody [EPR1965] (ab108313)参考文献

    ab108313 has not yet been referenced specifically in any publications.

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