概述

  • 产品名称Anti-Cip4抗体
    参阅全部 Cip4 一抗
  • 描述
    小鼠单克隆抗体to Cip4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: YGLLSEAELE VVPIIAKCLE GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL GTPSDGRPEL RGPGRSRTKR WPFGKKNKT, corresponding to amino acids 231-330 of Human Cip4

性能

应用

Our Abpromise guarantee covers the use of ab56545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
    • 组织特异性Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
    • 序列相似性Belongs to the FNBP1 family.
      Contains 1 FCH domain.
      Contains 1 REM (Hr1) repeat.
      Contains 1 SH3 domain.
    • 翻译后修饰Tyrosine phosphorylated. Also phosphorylated by PKA.
    • 细胞定位Cytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cdc42 interacting protein 4 antibody
      • Cdc42 interaction protein 4 long isoform antibody
      • Cdc42-interacting protein 4 antibody
      • CG11341 antibody
      • CG15015 PA antibody
      • Cip 4 antibody
      • CIP4 antibody
      • CIP4_HUMAN antibody
      • DCIP4 antibody
      • hSTP antibody
      • Protein Felic antibody
      • Salt tolerant protein antibody
      • Salt tolerator antibody
      • STOT antibody
      • STP antibody
      • Thyroid hormone receptor interactor 10 antibody
      • Thyroid receptor interacting protein 10 antibody
      • Thyroid receptor-interacting protein 10 antibody
      • TR-interacting protein 10 antibody
      • TRIP 10 antibody
      • TRIP-10 antibody
      • trip10 antibody
      • Truncated Cdc42 interaction protein 4 antibody
      see all

    Anti-Cip4 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56545 Cip4 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-Cip4 antibody (ab56545)参考文献

    ab56545 has not yet been referenced specifically in any publications.

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