概述

  • 产品名称Cinnabarinic acid
  • 描述
    Endogenous mGlu4 selective agonist
  • 生物学描述Endogenous selective mGlu4 agonist; generated by autoxidation of the tryptophan metabolite 3-hydroxyanthranilic acid. Activates mGlu4 receptors in transiently transfected HEK293 cells, and is devoid of activity on other mGlu receptor subtypes (mGlu1, 2, 5, 6, 7, and 8). Protects against NMDA-induced excitotoxic cell death.
  • 纯度> 98%

性能

  • 化学名称2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
  • 分子量300.23
  • 化学结构Chemical Structure
  • 分子式C14H8N2O6
  • CAS编号606-59-7
  • PubChem识别号114918
  • 存放说明Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 25 mM (requires warming)
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESC1=CC(=C2C(=C1)OC3=CC(=O)C(=C(C3=N2)C(=O)O)N)C(=O)O
  • 来源

    Synthetic

    Cinnabarinic acid (ab120506)参考文献

    This product has been referenced in:
    • Fazio F  et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol Pharmacol 81:643-56 (2012). Read more (PubMed: 22311707) »
    • Hiramatsu R  et al. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J Cell Biochem 103:42-53 (2008). Read more (PubMed: 17476692) »
    • Manthey MK  et al. Mechanism of reaction of 3-hydroxyanthranilic acid with molecular oxygen. Biochim Biophys Acta 1034:207-12 (1990). Read more (PubMed: 2162210) »

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