功能Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
组织特异性Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.
序列相似性Belongs to the cingulin family.
结构域Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1.
细胞定位Cell junction > tight junction. Localizes to the apical junction complex composed of tight and adherens junctions.
ab117796 at 1 µg/ml staining Cingulin in 293T cell lysate immunoprecipitated using ab117796 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with exposure time of 3 seconds
Anti-Cingulin antibody (ab117796)参考文献
has not yet been referenced specifically in any publications.