Anti-CIITA抗体(ab28349)
Key features and details
- Rabbit polyclonal to CIITA
- Suitable for: ELISA, IP, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CIITA抗体
参阅全部 CIITA 一抗 -
描述
兔多克隆抗体to CIITA -
宿主
Rabbit -
经测试应用
适用于: ELISA, IP, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment, corresponding to amino acids 1-333 of Human CIITA
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.01% Sodium azide -
Concentration information loading...
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纯度
Whole antiserum -
纯化说明
This product was prepared from monospecific antiserum by delipidation and defibrination. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab28349于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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说明 |
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ELISA
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
靶标
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功能
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). -
疾病相关
Bare lymphocyte syndrome 2 -
序列相似性
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
结构域
The acetyltransferase domain is necessary for activation of both class I and class II transcription.
The GTP-binding motif doesn't confer GTPase activity but promotes nuclear localization. -
翻译后修饰
Autophosphorylated, affecting interaction with TAF7. -
细胞定位
Nucleus. Nucleus, PML body. Recruited to PML body by PML. - Information by UniProt
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数据库链接
- Entrez Gene: 4261 Human
- Omim: 600005 Human
- SwissProt: P33076 Human
- Unigene: 701991 Human
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别名
- C2TA antibody
- C2TA_HUMAN antibody
- CIITA antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab28349 被引用在 1 文献中.
- Casals C et al. Lipopolysaccharide up-regulates MHC class II expression on dendritic cells through an AP-1 enhancer without affecting the levels of CIITA. J Immunol 178:6307-15 (2007). Mouse . PubMed: 17475859