概述

  • 产品名称
  • 描述
    兔多克隆抗体to CIDE A
  • 特异性
    Does not recognise CIDE-B.
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Synthetic peptide, corresponding to amino acids 200-214 of Mouse CIDE A.

  • 阳性对照
    • Tissue lysate of murine heart. An approximately 25 kDa band can be detected.

性能

应用

Our Abpromise guarantee covers the use of ab8402 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 25 kDa.Can be blocked with CIDE A peptide (ab8434).
ICC/IF Use a concentration of 20 µg/ml.

靶标

  • 相关性
    Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICARD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B (for cell death inducing DFF like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE A is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE A is expressed in many tissues.
  • 细胞定位
    Nuclear. Cytoplasm; mitochondrial envelope; lipid droplet.
  • 数据库链接
  • 别名
    • Cell death activator CIDE A antibody
    • Cell Death Inducing DFFA Like Effector A antibody
    • cell death inducing DNA fragmentation factor, alpha subunit like effector A antibody
    • CIDE-A antibody
    • CIDEA antibody
    see all

图片

  • Anti-CIDE A antibody (ab8402) at 1/500 dilution + Murine heart tissue lysate

    Predicted band size : 25 kDa
  • Immunofluorescence of CIDE-A in Mouse Heart cells using ab8402 at 20 ug/ml.

文献

This product has been referenced in:
  • Binder AK  et al. Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation. PLoS One 11:e0146518 (2016). Read more (PubMed: 26745373) »

See 1 Publication for this product

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