概述

  • 产品名称
  • 描述
    小鼠单克隆抗体to CIB1
  • 经测试应用
    适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-192 of Human CIB1

  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

性能

应用

Our Abpromise guarantee covers the use of ab56664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
WB
  • 应用说明
    WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
    • 组织特异性
      Ubiquitous.
    • 序列相似性
      Contains 2 EF-hand domains.
    • 细胞定位
      Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Calcium and integrin binding 1 (calmyrin) antibody
      • Calcium and integrin binding protein 1 antibody
      • Calcium and integrin-binding protein 1 antibody
      • Calcium- and integrin-binding protein antibody
      • Calmyrin antibody
      • CIB antibody
      • CIB1 antibody
      • CIB1_HUMAN antibody
      • CIBP antibody
      • DNA PKcs interacting protein antibody
      • DNA-dependent protein kinase interacting protein antibody
      • DNA-PK interaction protein antibody
      • DNA-PKcs-interacting protein antibody
      • Human Snk interacting protein 2 to 28 mRNA complete cds antibody
      • Kinase interacting protein antibody
      • Kinase-interacting protein 1 antibody
      • Kinase-interacting protein antibody
      • KIP antibody
      • KIP1 antibody
      • PRKDCIP antibody
      • SIP2 28 antibody
      • SIP2-28 antibody
      • SNK interacting protein 2 to 28 antibody
      • SNK-interacting protein 2-28 antibody
      see all

    图片

    • CIB1 antibody (ab56664) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.
    • Western blot against tagged recombinant protein immunogen using ab56664 CIB1 antibody at 1ug/ml. Predicted band size of immunogen is 47 kDa

    文献

    This product has been referenced in:
    • Raab M  et al. Differential binding of ICln in platelets to integrin-derived activating and inhibitory peptides. Biochem Biophys Res Commun 392:258-63 (2010). WB ; Human . Read more (PubMed: 20034469) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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