概述

  • 产品名称Anti-CIB1抗体
    参阅全部 CIB1 一抗
  • 描述
    小鼠单克隆抗体to CIB1
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-192 of Human CIB1

性能

应用

Our Abpromise guarantee covers the use of ab56664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
    • 组织特异性Ubiquitous.
    • 序列相似性Contains 2 EF-hand domains.
    • 细胞定位Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Calcium and integrin binding 1 (calmyrin) antibody
      • Calcium and integrin binding protein 1 antibody
      • Calcium and integrin-binding protein 1 antibody
      • Calcium- and integrin-binding protein antibody
      • Calmyrin antibody
      • CIB antibody
      • CIB1 antibody
      • CIB1_HUMAN antibody
      • CIBP antibody
      • DNA PKcs interacting protein antibody
      • DNA-dependent protein kinase interacting protein antibody
      • DNA-PK interaction protein antibody
      • DNA-PKcs-interacting protein antibody
      • Human Snk interacting protein 2 to 28 mRNA complete cds antibody
      • Kinase interacting protein antibody
      • Kinase-interacting protein 1 antibody
      • Kinase-interacting protein antibody
      • KIP antibody
      • KIP1 antibody
      • PRKDCIP antibody
      • SIP2 28 antibody
      • SIP2-28 antibody
      • SNK interacting protein 2 to 28 antibody
      • SNK-interacting protein 2-28 antibody
      see all

    Anti-CIB1 antibody 图像

    • CIB1 antibody (ab56664) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.
    • Western blot against tagged recombinant protein immunogen using ab56664 CIB1 antibody at 1ug/ml. Predicted band size of immunogen is 47 kDa

    Anti-CIB1 antibody (ab56664)参考文献

    This product has been referenced in:
    • Raab M  et al. Differential binding of ICln in platelets to integrin-derived activating and inhibitory peptides. Biochem Biophys Res Commun 392:258-63 (2010). WB ; Human . Read more (PubMed: 20034469) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"