Anti-CHX10抗体- ChIP Grade (ab16142)

概述

  • 产品名称Anti-CHX10抗体- ChIP Grade
    参阅全部 CHX10 一抗
  • 描述
    羊多克隆抗体to CHX10 - ChIP Grade
  • 经测试应用适用于: WB, ChIP, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human
  • 免疫原

    Recombinant fragment, corresponding to N terminal amino acids 1-131 of Human CHX10.

  • 阳性对照
    • Rat or mouse retinal tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab16142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 46 kDa. Detects a band of approximately 46 kDa mouse and rat retinal tissue lysates.
ChIP Use at an assay dependent dilution. PubMed: 18272592
IHC-P Use at an assay dependent concentration. PubMed: 20459797

靶标

  • 功能Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.
  • 组织特异性Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate.
  • 疾病相关Defects in VSX2 are the cause of microphthalmia isolated type 2 (MCOP2) [MIM:610093]; also known as isolated clinical anophthalmia. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.
    Defects in VSX2 are the cause of microphthalmia with cataracts and iris abnormalities (MCOPCTI) [MIM:610092].
    Defects in VSX2 are the cause of microphthalmia isolated with coloboma type 3 (MCOPCB3) [MIM:610092]; also known as isolated colobomatous microphthalmia 3. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure).
  • 序列相似性Belongs to the paired homeobox family.
    Contains 1 CVC domain.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C elegans ceh 10 homeo domain containing homolog antibody
    • Ceh 10 homeo domain containing homolog (C. elegans) antibody
    • Ceh 10 homeo domain containing homolog antibody
    • Ceh 10 homeodomain containing homolog antibody
    • Ceh 10 homeodomain containing homolog (C. elegans) antibody
    • Ceh-10 homeodomain-containing homolog antibody
    • Ceh10 homeo domain containing homolog antibody
    • Ceh10 homeodomain containing homolog antibody
    • CHX 10 antibody
    • Homeobox protein CHX 10 antibody
    • Homeobox protein CHX10 antibody
    • HOX 10 antibody
    • HOX10 antibody
    • MCOP 2 antibody
    • MCOP2 antibody
    • MCOPCB 3 antibody
    • MCOPCB3 antibody
    • RET 1 antibody
    • RET1 antibody
    • Visual system homeobox 2 antibody
    • Vsx 2 antibody
    • Vsx2 antibody
    • VSX2_HUMAN antibody
    see all

Anti-CHX10 antibody - ChIP Grade 图像

  • Western blot analysis using ab161412 at 1 µg/ml on rat liver (A), rat retina tissue lysate (B), mouse liver (C) and mouse retina tissue lysate (D).

Anti-CHX10 antibody - ChIP Grade (ab16142)参考文献

This product has been referenced in:
  • Rapicavoli NA  et al. The long noncoding RNA RNCR2 directs mouse retinal cell specification. BMC Dev Biol 10:49 (2010). IHC-P ; Mouse . Read more (PubMed: 20459797) »
  • Bharti K  et al. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135:1169-78 (2008). ChIP ; Mouse . Read more (PubMed: 18272592) »

See all 2 Publications for this product

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