概述

  • 产品名称Anti-CHST14抗体
  • 描述
    兔多克隆抗体to CHST14
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 177-205 of Human CHST14 (NP_569735.1).

  • 阳性对照
    • Mouse stomach tissue lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab116308 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG

应用

Our Abpromise guarantee covers the use of ab116308 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.

靶标

  • 功能Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA.
  • 组织特异性Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.
  • 疾病相关Defects in CHST14 are the cause of Ehlers-Danlos syndrome musculocontractural type (EDSMC) [MIM:601776]. It is a form of Ehlers-Danlos syndrome characterized by distinctive craniofacial dysmorphism, congenital contractures of thumbs and fingers, clubfeet, severe kyphoscoliosis, muscular hypotonia, hyperextensible thin skin with easy bruisability and atrophic scarring, wrinkled palms, joint hypermobility, and ocular involvement.
  • 序列相似性Belongs to the sulfotransferase 2 family.
  • 细胞定位Golgi apparatus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2600016L03Rik antibody
    • ATCS antibody
    • Carbohydrate (N acetylgalactosamine 4 0) sulfotransferase 14 antibody
    • Carbohydrate sulfotransferase 14 antibody
    • CHST14 antibody
    • CHSTE_HUMAN antibody
    • D4ST-1 antibody
    • D4st1 antibody
    • Dermatan 4-sulfotransferase 1 antibody
    • hD4ST1 antibody
    • RP23-286G12.2 antibody
    • UNQ1925/PRO4400 antibody
    see all

Anti-CHST14 antibody 图像

  • Anti-CHST14 antibody (ab116308) at 1/100 dilution + Mouse stomach tissue lysates at 15 µg

    Predicted band size : 43 kDa

Anti-CHST14 antibody (ab116308)参考文献

ab116308 has not yet been referenced specifically in any publications.

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