功能Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
组织特异性Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
All lanes : Anti-CHRNA10 antibody (ab110063) at 1/500 dilution
Lane 1 : Extracts from A549 cells Lane 2 : Extracts from COLO cells Lane 3 : Extracts from 293 cells Lane 4 : Extracts from HeLa cells Lane 5 : Extracts from A549 cells with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size : 50 kDa
Anti-CHRNA10 antibody (ab110063)参考文献
has not yet been referenced specifically in any publications.