概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-NKDGVLVDEFGLPQ
    • 氨基酸202 to 215

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-CHMP5 antibody (ab31282)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • apoptosis-related protein PNAS-2
    • C9orf83
    • CGI 34
    • Charged multivesicular body protein 5
    • CHMP 5
    • CHMP family, member 5
    • chmp5
    • CHMP5_HUMAN
    • Chromatin modifying protein 5
    • Chromatin-modifying protein 5
    • Chromosome 9 open reading frame 83
    • HGNC:26942
    • HSPC177
    • hVps60
    • PNAS 2
    • SNF7 domain containing protein 2
    • SNF7 domain-containing protein 2
    • SNF7DC2
    • Vacuolar protein sorting 60
    • Vacuolar protein sorting-associated protein 60
    • Vps60
    see all
  • 功能Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
  • 序列相似性Belongs to the SNF7 family.
  • 细胞定位Cytoplasm > cytosol. Endosome membrane. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
  • Information by UniProt

CHMP5 peptide (202-215) (ab45718)参考文献

ab45718 has not yet been referenced specifically in any publications.

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