概述

  • 产品名称Anti-CHMP4A抗体
    参阅全部 CHMP4A 一抗
  • 描述
    兔多克隆抗体to CHMP4A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 210-259 (ELEQEELAQE LLNVGDKEEE PSVKLPSVPS THLPAGPAPK VDEDEEALKQ) of Human CHMP4A (NP_054888).

  • 阳性对照
    • 721_B cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Constituents: 98% PBS, 2% Sucrose
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab116340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In the ESCRT-III complex, it probably serves as an acceptor for ESCRT-I complex on endosomal membranes. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins, via the association of CHMP4 proteins with PDCD6IP/AIP1, a protein directly recruited by HIV-1 p6 protein that functions at sites of viral Gag assembly and budding.
  • 细胞定位Cytoplasmic: Cytoplasmic vesicle membrane. Membrane-associated - localizes to large vesicle-like structures.
  • 数据库链接
  • 别名
    • C14orf123 antibody
    • Charged multivesicular body protein 4a antibody
    • Chromatin modifying protein 4a antibody
    • HSPC134 antibody
    • SHAX2 antibody
    see all

Anti-CHMP4A antibody 图像

  • Anti-CHMP4A antibody (ab116340) at 1 µg/ml + 721_B cell lysate at 10 µg

    Predicted band size : 25 kDa

Anti-CHMP4A antibody (ab116340)参考文献

ab116340 has not yet been referenced specifically in any publications.

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