概述

  • 产品名称Anti-CHMP1B抗体
    参阅全部 CHMP1B 一抗
  • 描述
    兔多克隆抗体to CHMP1B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (KIKKAIQKGN MEVARIHAEN AIRQKNQAVN FLRMSARVDA VAARVQTAVT) of Human CHMP1B (NP_065145).

  • 阳性对照
    • Human fetal heart lysate.

性能

应用

Our Abpromise guarantee covers the use of ab105706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.
  • 组织特异性Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain.
  • 序列相似性Belongs to the SNF7 family.
  • 细胞定位Cytoplasm > cytosol. Endosome. Late endosome membrane. Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2810405I11Rik antibody
    • C10orf2 antibody
    • C18 ORF2 antibody
    • C18orf2 antibody
    • Charged multivesicular body protein 1b antibody
    • CHM1B_HUMAN antibody
    • CHMP family, member 1B antibody
    • CHMP1.5 antibody
    • CHMP1b antibody
    • Choromosome 18 open reading frame 2 antibody
    • Chromatin-modifying protein 1b antibody
    • hVps46-2 antibody
    • vacuolar protein sorting 46-2 antibody
    • Vacuolar protein sorting-associated protein 46-2 antibody
    • Vps46-2 antibody
    • Vps46B antibody
    see all

Anti-CHMP1B antibody 图像

  • Anti-CHMP1B antibody (ab105706) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Predicted band size : 22 kDa

Anti-CHMP1B antibody (ab105706)参考文献

ab105706 has not yet been referenced specifically in any publications.

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