概述

  • 产品名称Anti-CHMP1a抗体
    参阅全部 CHMP1a 一抗
  • 描述
    兔多克隆抗体to CHMP1a
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-196 of Human CHMP1a (NP_002759).

  • 阳性对照
    • Transfected 293T cell line

性能

应用

Our Abpromise guarantee covers the use of ab104103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 22 kDa. This antibody has only been tested in WB against the recombinant protein used as an immunogen. We have no data on the detection of endogenous protein.

靶标

  • 功能Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
  • 组织特异性Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.
  • 序列相似性Belongs to the SNF7 family.
  • 细胞定位Cytoplasm. Endosome membrane. Nucleus matrix. The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Charged multivesicular body protein 1a antibody
    • CHM1A_HUMAN antibody
    • CHMP1a antibody
    • Chromatin modifying protein 1a antibody
    • Chromatin-modifying protein 1a antibody
    • hVps46 1 antibody
    • hVps46-1 antibody
    • KIAA0047 antibody
    • Metalloprotease 1 antibody
    • PCOLN3 antibody
    • Procollagen (type III) N endopeptidase antibody
    • PRSM1 antibody
    • Vacuolar protein sorting 46 1 antibody
    • Vacuolar protein sorting-associated protein 46-1 antibody
    • Vps46 1 antibody
    • Vps46-1 antibody
    see all

Anti-CHMP1a antibody 图像

  • All lanes : Anti-CHMP1a antibody (ab104103) at 5 µg/ml

    Lane 1 : CHMP1A transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate.

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 22 kDa

Anti-CHMP1a antibody (ab104103)参考文献

This product has been referenced in:
  • Mochida GH  et al. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet 44:1260-4 (2012). WB, IHC-P . Read more (PubMed: 23023333) »

See 1 Publication for this product

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