Anti-Chloride Channel 5抗体(ab97482)

概述

• 产品名称
  Anti-Chloride Channel 5抗体
  参阅全部 Chloride Channel 5 一抗
• 描述
  兔多克隆抗体to Chloride Channel 5
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Rat, Rabbit, Guinea pig, Pig
• 免疫原

  Recombinant protein fragment containing a sequence corresponding to a region within amino acids 62-363 of Human chloride channel 5 (NP_000075)

  Run BLAST with Run BLAST with
• 阳性对照
  • A431 whole cell lysate, HepG2 and Raji lysates.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • More Ion Channels

  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Raji membrane extract lysate (ab30126)
  • HepG2 whole cell lysate (ab7900)
  • A431 whole cell lysate (ab7909)

应用

靶标

• 功能
  Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
• 组织特异性
  Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle.
• 疾病相关
  Hypophosphatemic rickets, X-linked recessive
  Nephrolithiasis 2
  Nephrolithiasis 1
  Low molecular weight proteinuria with hypercalciuria and nephrocalcinosis
• 序列相似性
  Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
  Contains 2 CBS domains.
• 翻译后修饰
  Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.
• 细胞定位
  Golgi apparatus membrane. Endosome membrane. Cell membrane.

• Target information above from: UniProt accession P51795 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 1184 Human
  • Entrez Gene: 100008741 Rabbit
  • Entrez Gene: 25749 Rat
  • Omim: 300008 Human
  • SwissProt: Q99P66 Guinea pig
  • SwissProt: P51795 Human
  • SwissProt: Q9GKE7 Pig
  • SwissProt: Q9TTU3 Rabbit

  • SwissProt: P51796 Rat
  • Unigene: 166486 Human
  • Unigene: 745501 Human
  • Unigene: 10337 Rat

  see all
• 别名
  • Chloride channel protein 5 antibody
  • Chloride channel voltage sensitive 5 antibody
  • Chloride transporter ClC-5 antibody

  • ClC-5 antibody
  • CLC5 antibody
  • CLCK2 antibody
  • CLCN5 antibody
  • CLCN5_HUMAN antibody
  • DENTS antibody
  • H(+)/Cl(-) exchange transporter 5 antibody
  • hCIC-K2 antibody
  • NPHL1 antibody
  • NPHL2 antibody
  • Voltage gated chloride ion channel CLCN5 antibody
  • XLRH antibody
  • XRN antibody

  see all

实验方案

• Western blot protocols