Anti-Chlamydia trachomatis MOMP抗体[BIOD166] (ab20881)

概述

  • 产品名称Anti-Chlamydia trachomatis MOMP抗体[BIOD166]
    参阅全部 Chlamydia trachomatis MOMP 一抗
  • 描述
    小鼠单克隆抗体[BIOD166] to Chlamydia trachomatis MOMP
  • 特异性Ab20881 is specific for major outer membrane protein (MOMP) of Chlamydia trachomatis. No reactivity with C. pneumoniae.
  • 经测试应用适用于: ICC/IF, WB, ELISAmore details
  • 种属反应性
    与反应: Chlamydia trachomatis
    不与反应: Chlamydia pneumoniae
  • 免疫原

    Chlamydia trachomatis elementary bodies.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 0.01M PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号BIOD166
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab20881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 21628561
WB Use at an assay dependent concentration. PubMed: 21628561
ELISA 1/20 - 1/200.

靶标

  • 相关性Chlamydia is caused by the bacterium Chlamydia trachomatis. The intracytoplasmic inclusions caused by the bacterium are draped around the infected cell's nucleus. Chlamydia trachomatis is an intracellular organism that has a genome size of approximately 500-1000 kilobases and contains both RNA and DNA. The organism is also extremely temperature sensitive and must be refrigerated at 4°C as soon as a sample is obtained. Colonization of Chlamydia begins with attachment to sialic acid receptors on the eye, throat or genitalia. It persists at body sites that are inaccessible to phagocytes, T cells, and B cells. It also exists as 15 different serotypes. These serotypes cause four major diseases in humans: endemic trachoma (caused by serotypes A and C), sexually transmitted disease and inclusion conjunctivitis (caused by serotypes D and K), and lymphogranuloma venereum (caused by serotypes L1, L2, and L3). Studies reveal that Chlamydia, because of its cell wall, is able to inhibit phagolysosome fusion in phagocytes. The cell wall is proposed to be Gram negative in that it contains an outer lipopolysaccharide membrane, but it lacks peptidoglycan in its cell wall. This lack of peptidoglycan is shown by the inability to detect muramic acid and antibodies directed against it. It may, however, contain a carboxylated sugar other than muramic acid. The proposed structure consists of a major outer membrane protein cross linked with disulfide bonds. It also contains cysteine rich proteins (CRP) that may be the functional equivalent to peptidoglycan. This unique structure allows for intracellular division and extracellular survival (Hatch 1996). Chlamydia usually infects the cervix and fallopian tubes of women and the urethra of men. Chlamydial infections are believed to be one of the most common of all STDs. It is generally thought that in a population of 15 million, there are up to 300,000 cases of chlamydia each year. Thus, there are many undiagnosed cases of chlamydia in the community. It has been estimated that the true prevalence of chlamydia in the sexually active population may be in the order of 5% to 10%. Chlamydia is one of the leading causes of blindness in underdeveloped countries.
  • 细胞定位Outer membrane; multi pass membrane protein.
  • 数据库链接
    see all
  • 别名
    • Major Outer Membrane Protein antibody
    • MOMP antibody
    • omp1 antibody
    • omp1F antibody
    • Omp1L1 antibody
    • ompA antibody
    • ompIL2 antibody
    see all

Anti-Chlamydia trachomatis MOMP antibody [BIOD166] (ab20881)参考文献

This product has been referenced in:
  • Nguyen BD  et al. Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis. Proc Natl Acad Sci U S A 108:10284-9 (2011). ICC/IF, WB . Read more (PubMed: 21628561) »

See 1 Publication for this product

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