概述

  • 产品名称
    CHIR99021
  • 描述
    Potent, highly selective GSK3 inhibitor
  • 生物学描述
    Potent, highly selective aminopyrimidine GSK3 inhibitor (IC50 values are 6.7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization.
  • 纯度
    > 98%

性能

文献

This product has been referenced in:
  • Ye S  et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One 7:e35892 (2012). Read more (PubMed: 22540008) »
  • Li W  et al. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27:2992-3000 (2009). Read more (PubMed: 19839055) »
  • Ring DB  et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52:588-95 (2003). Read more (PubMed: 12606497) »

See all 2 Publications for this product

客户评价及客户问答


The lab let me know that we actually qualify CHIR99021 by TLC, MS and UV (not by HPLC). The absorption is measured by UV λ max: 279 nm.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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