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Cell-permeable, selective inhibitor of protein kinase C (IC50 = 0.66 μM); Competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Activates MAPK pathways, independent of PKC inhibition. Inhibits BclXL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"