概述

  • 产品名称Anti-Chd1抗体
  • 描述
    兔多克隆抗体to Chd1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rabbit, Horse, Guinea pig, Dog
  • 免疫原

    Synthetic peptide corresponding to Human Chd1 aa 1332-1381 (internal sequence).
    Sequence:

    RKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRERS


    Database link: O14646

  • 阳性对照
    • Human fetal stomach lysate

性能

应用

Our Abpromise guarantee covers the use of ab94848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 197 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
  • 序列相似性Belongs to the SNF2/RAD54 helicase family.
    Contains 2 chromo domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • 结构域The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
  • 细胞定位Nucleus. Cytoplasm. Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ATP dependent helicase CHD 1 antibody
    • ATP-dependent helicase CHD1 antibody
    • CHD 1 antibody
    • CHD-1 antibody
    • Chd1 antibody
    • CHD1_HUMAN antibody
    • Chromodomain helicase DNA binding protein 1 antibody
    • Chromodomain-helicase-DNA-binding protein 1 antibody
    • DKFZp686E2337 antibody
    • OTTHUMP00000222625 antibody
    see all

Anti-Chd1 antibody 图像

  • Anti-Chd1 antibody (ab94848) at 1 µg/ml + Human fetal stomach lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 197 kDa

Anti-Chd1 antibody (ab94848)参考文献

ab94848 has not yet been referenced specifically in any publications.

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