概述

  • 产品名称CGP 7930
  • 描述
    Positive GABAB receptor allosteric modulator
  • 生物学描述Positive GABAB receptor allosteric modulator (EC50 values are 5.37 and 4.60 μM, respectively). Increases receptor agonist affinity and signal transduction efficacy. Also shown to potentiate receptor response to baclofen (ab120325).
  • 纯度> 98%

性能

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    CGP 7930 (ab120492)参考文献

    This product has been referenced in:
    • Adams CL & Lawrence AJ CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Rev 13:308-16 (2007). Read more (PubMed: 17894647) »
    • Chen Y  et al. GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. Br J Pharmacol 144:926-32 (2005). Read more (PubMed: 15711597) »
    • Carai MA  et al. In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor. Eur J Pharmacol 504:213-6 (2004). Read more (PubMed: 15541424) »

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