概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab39982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.
  • 疾病相关Heterotaxy, visceral, 2, autosomal (HTX2) [MIM:605376]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Transposition of the great arteries dextro-looped 2 (DTGA2) [MIM:613853]: A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Contains 1 EGF-like domain.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Cell membrane. Secreted. Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CFC 1 antibody
    • CFC1 antibody
    • CFC1_HUMAN antibody
    • CFC1B antibody
    • CR 1 antibody
    • Cripto 1 antibody
    • Cripto FRL 1 cryptic family 1 antibody
    • CRYPTIC antibody
    • Cryptic family 1 antibody
    • Cryptic family protein 1 antibody
    • Cryptic gene antibody
    • Cryptic protein antibody
    • DTGA2 antibody
    • FLJ77897 antibody
    • FRL 1 antibody
    • Heterotaxy 2 (autosomal dominant) antibody
    • HTX2 antibody
    • MGC133213 antibody
    see all

Anti-CFC1 antibody 图像

  • ab39982 (2µg/ml) staining of paraffin embedded Mouse Embryo Liver shows staining of the hepatocyte cell membranes. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.

Anti-CFC1 antibody (ab39982)参考文献

ab39982 has not yet been referenced specifically in any publications.

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