Anti-Ceruloplasmin抗体(ab47785)

概述

  • 产品名称Anti-Ceruloplasmin抗体
    参阅全部 Ceruloplasmin 一抗
  • 描述
    鸡多克隆抗体to Ceruloplasmin
  • 经测试应用适用于: WB, ELISA, more details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein: highly purified human ceruloplasmin isolated from human serum

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgY
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab47785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
Depletion
  • 应用说明Depletion: Use at an assay dependent dilution.
    ELISA: 1/200 - 1/500.
    WB: 1/1000. Predicted molecular weight: 122 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
    • 组织特异性Expressed by the liver and secreted in plasma.
    • 疾病相关Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
      Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
    • 序列相似性Belongs to the multicopper oxidase family.
      Contains 3 F5/8 type A domains.
      Contains 6 plastocyanin-like domains.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CERU_HUMAN antibody
      • Ceruloplasmin antibody
      • CP 2 antibody
      • CP antibody
      • CP2 antibody
      • Ferroxidase antibody
      see all

    Anti-Ceruloplasmin antibody (ab47785)参考文献

    ab47785 has not yet been referenced specifically in any publications.

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