概述

  • 产品名称Anti-Ceruloplasmin抗体
    参阅全部 Ceruloplasmin 一抗
  • 描述
    山羊多克隆抗体to Ceruloplasmin
  • 特异性By immunoelectrophoresis and ELISA this antibody reacts specifically with ceruloplasmin. No antibody was detected against other serum proteins.
  • 经测试应用适用于: WB, ELISA, ICCmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Unfortunately, this information is considered to be commercially sensitive

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab19171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 122 kDa.
ELISA 1/100 - 1/1000.
ICC 1/200 - 1/2000.

靶标

  • 功能Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
  • 组织特异性Expressed by the liver and secreted in plasma.
  • 疾病相关Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
    Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
  • 序列相似性Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 6 plastocyanin-like domains.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CERU_HUMAN antibody
    • Ceruloplasmin antibody
    • CP 2 antibody
    • CP antibody
    • CP2 antibody
    • Ferroxidase antibody
    see all

Anti-Ceruloplasmin antibody (ab19171)参考文献

This product has been referenced in:
  • Hatori Y  et al. Functional partnership of the copper export machinery and glutathione balance in human cells. J Biol Chem 287:26678-87 (2012). WB ; Mouse . Read more (PubMed: 22648419) »
  • Mittag J  et al. Serum copper as a novel biomarker for resistance to thyroid hormone. Biochem J 443:103-9 (2012). WB . Read more (PubMed: 22220593) »

See all 3 Publications for this product

Product Wall

Thank you for your patience. I am afraid that the originator of the product can only confirm that the antibody was made with the whole protein and not a synthesized peptide, and that the goat was immunized with native protein ceruloplasmin. I am ...

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Thank you for your enquiry. Ab8749 is a polyclonal antibody raised to the full length protein, and will therefore consist of a mixed population of IgGs, each of which will recognise a different epitope. The immunogen for Ab19171 is considered c...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"