Anti-Ceruloplasmin抗体[3B11] (ab51083)

概述

  • 产品名称
    Anti-Ceruloplasmin抗体[3B11]
    参阅全部 Ceruloplasmin 一抗
  • 描述
    小鼠单克隆抗体[3B11] to Ceruloplasmin
  • 经测试应用
    适用于: IHC-P, ChIP, WB, IP, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein purified from Human plasma

  • 阳性对照
    • Human plasma
  • 常规说明

    This product was changed from ascites to tissue culture supernatant on 18th September 2017. Lot numbers higher than GR162822 will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

性能

应用

Our Abpromise guarantee covers the use of ab51083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
ChIP Use at an assay dependent concentration.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 122 kDa.
IP Use at an assay dependent concentration.

Use 2μg

ELISA Use at an assay dependent concentration.

靶标

  • 功能
    Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
  • 组织特异性
    Expressed by the liver and secreted in plasma.
  • 疾病相关
    Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
    Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
  • 序列相似性
    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 6 plastocyanin-like domains.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CERU_HUMAN antibody
    • Ceruloplasmin antibody
    • CP 2 antibody
    • CP antibody
    • CP2 antibody
    • Ferroxidase antibody
    see all

Anti-Ceruloplasmin antibody [3B11] 图像

  • All lanes : Anti-Ceruloplasmin antibody [3B11] (ab51083) at 1/1000 dilution

    Lane 1 : Ceruloplasmin isolated from human plasma
    Lane 2 : Human plasma


    Predicted band size : 122 kDa
    Observed band size : 140 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 120 kDa. We are unsure as to the identity of these extra bands.

Anti-Ceruloplasmin antibody [3B11] (ab51083)参考文献

This product has been referenced in:
  • Guo Z  et al. Differential urinary glycoproteome analysis of type 2 diabetic nephropathy using 2D-LC-MS/MS and iTRAQ quantification. J Transl Med 13:371 (2015). WB . Read more (PubMed: 26608305) »
  • Liu X  et al. An individual urinary proteome analysis in normal human beings to define the minimal sample number to represent the normal urinary proteome. Proteome Sci 10:70 (2012). WB . Read more (PubMed: 23170922) »

See all 3 Publications for this product

Product Wall


The lab let me know that the immunogen of ab51083 is a protein purified from Human plasma.
And thus, the protein sequence is full and has not been mapped. This would apply also for the epitope which has not been mapped either.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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