Anti-Ceruloplasmin抗体[3B11] (ab51083)

概述

  • 产品名称Anti-Ceruloplasmin抗体[3B11]
    参阅全部 Ceruloplasmin 一抗
  • 描述
    小鼠单克隆抗体[3B11] to Ceruloplasmin
  • 经测试应用适用于: WB, IP, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein purified from Human plasma

  • 阳性对照
    • Human plasma

性能

应用

Our Abpromise guarantee covers the use of ab51083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 122 kDa.
IP Use at an assay dependent dilution. 1µg/400µl of lysates.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
  • 组织特异性Expressed by the liver and secreted in plasma.
  • 疾病相关Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
    Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
  • 序列相似性Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 6 plastocyanin-like domains.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CERU_HUMAN antibody
    • Ceruloplasmin antibody
    • CP 2 antibody
    • CP antibody
    • CP2 antibody
    • Ferroxidase antibody
    see all

Anti-Ceruloplasmin antibody [3B11] 图像

  • All lanes : Anti-Ceruloplasmin antibody [3B11] (ab51083) at 1/1000 dilution

    Lane 1 : Ceruloplasmin isolated from human plasma
    Lane 2 : Human plasma


    Predicted band size : 122 kDa
    Observed band size : 140 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 120 kDa. We are unsure as to the identity of these extra bands.

Anti-Ceruloplasmin antibody [3B11] (ab51083)参考文献

This product has been referenced in:
  • Jarkovska K  et al. Development of ovarian hyperstimulation syndrome: interrogation of key proteins and biological processes in human follicular fluid of women undergoing in vitro fertilization. Mol Hum Reprod 17:679-92 (2011). WB ; Human . Read more (PubMed: 21697218) »

See 1 Publication for this product

Product Wall


The lab let me know that the immunogen of ab51083 is a protein purified from Human plasma.
And thus, the protein sequence is full and has not been mapped. This would apply also for the epitope which has not been mapped either.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"