Anti-CEP135抗体(ab75005)
Key features and details
- Rabbit polyclonal to CEP135
- Suitable for: ELISA, ICC/IF, WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-CEP135抗体 -
描述
兔多克隆抗体to CEP135 -
宿主
Rabbit -
经测试应用
适用于: ELISA, ICC/IF, WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
synthesized peptide derived from C-terminal region of human CEP135.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab75005于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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ICC/IF | (1) |
Use at an assay dependent concentration.
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WB |
1/500 - 1/1000. Predicted molecular weight: 134 kDa.
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说明 |
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ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
1/500 - 1/1000. Predicted molecular weight: 134 kDa. |
靶标
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功能
Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. -
疾病相关
Microcephaly 8, primary, autosomal recessive -
序列相似性
Belongs to the CEP135/TSGA10 family. -
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. - Information by UniProt
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数据库链接
- Entrez Gene: 9662 Human
- Entrez Gene: 381644 Mouse
- Omim: 611423 Human
- SwissProt: Q66GS9 Human
- SwissProt: Q6P5D4 Mouse
- Unigene: 518767 Human
- Unigene: 332452 Mouse
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别名
- centrosomal protein 135 kDa antibody
- centrosomal protein 135kDa antibody
- Centrosomal protein 4 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (35)
ab75005 被引用在 35 文献中.
- Bühler M et al. GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells. Life Sci Alliance 6:N/A (2023). PubMed: 36384894
- Magistrati E et al. Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1. EMBO Rep 23:e54160 (2022). PubMed: 34957672
- Chu Z & Gruss OJ Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells. Cells 11:N/A (2022). PubMed: 35406752
- Tátrai P & Gergely F Centrosome function is critical during terminal erythroid differentiation. EMBO J 41:e108739 (2022). PubMed: 35678476
- Mahen R cNap1 bridges centriole contact sites to maintain centrosome cohesion. PLoS Biol 20:e3001854 (2022). PubMed: 36282799