概述

  • 产品名称Anti-CENPT抗体
    参阅全部 CENPT 一抗
  • 描述
    兔多克隆抗体to CENPT
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region between amino acids 520-561 of Human CENPT (NP_079358.3 ).

  • 阳性对照
    • HeLa whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab114120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENP-T is one of the basic inner kinetochore proteins with most further proteins binding downstream, suggesting a fundamental role of CENP-T in kinetochore function.
    • 序列相似性Belongs to the CENPT family.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus. Chromosome > centromere > kinetochore. Localizes exclusively in the kinetochore domain of centromeres.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C16orf56 antibody
      • CENP T antibody
      • CENP-T antibody
      • Cenpt antibody
      • CENPT_HUMAN antibody
      • Centromere protein T antibody
      • Chromosome 16 open reading frame 56 antibody
      • ICEN22 antibody
      • Interphase centromere complex protein 22 antibody
      see all

    Anti-CENPT antibody 图像

    • Detection of CENPT by Western Blot of Immunprecipitate.
      Lane 1: An antibody to CENPT at 1µg/ml staining CENPT in HeLa whole cell lysate immunoprecipitated using ab114120 at 10µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Lane 2: Control IgG
      Detection: Chemiluminescence with exposure time of 3 seconds.

    Anti-CENPT antibody (ab114120)参考文献

    ab114120 has not yet been referenced specifically in any publications.

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