概述

  • 产品名称Anti-CENPC抗体
    参阅全部 CENPC 一抗
  • 描述
    兔多克隆抗体to CENPC
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 448-475 of Human CENPC (NP_001803.2)

  • 阳性对照
    • Jurkat cell line lysates

性能

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应用

Our Abpromise guarantee covers the use of ab107068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 107 kDa.

靶标

  • 功能Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
  • 序列相似性Belongs to the CENPC family.
  • 结构域The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.
  • 细胞定位Nucleus. Chromosome > centromere > kinetochore. Localizes exclusively in the kinetochore domain of centromeres.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CENP-C 1 antibody
    • CENP-C antibody
    • CENPC_HUMAN antibody
    • CENPC1 antibody
    • Centromere autoantigen C antibody
    • Centromere autoantigen C1 antibody
    • Centromere protein C 1 antibody
    • Centromere protein C antibody
    • hcp-4 antibody
    • ICEN7 antibody
    • Interphase centromere complex protein 7 antibody
    • MIF2 antibody
    see all

Anti-CENPC antibody 图像

  • Anti-CENPC antibody (ab107068) at 1/100 dilution + Jurkat cell line lysates at 35 µg

    Predicted band size : 107 kDa

Anti-CENPC antibody (ab107068)参考文献

ab107068 has not yet been referenced specifically in any publications.

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