Anti-Cellular Apoptosis Susceptibility抗体(ab27518)

概述

  • 产品名称Anti-Cellular Apoptosis Susceptibility抗体
    参阅全部 Cellular Apoptosis Susceptibility 一抗
  • 描述
    兔多克隆抗体to Cellular Apoptosis Susceptibility
  • 特异性Ab27518 recognises Cellular Apoptosis Susceptibility protein.
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide from N terminus of human Cellular Apoptosis Susceptibility.

  • 阳性对照
    • Human Liver carcinoma, HeLa cells and NIH 3T3 cells.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab27518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明IHC-P: 1/100 for 10 min at room temperature. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min and then cool at room temperature for 20 min.
    WB: Use at a concentration of 0.5 - 2 µg/ml for 2 hours at room temperature. Predicted molecular weight: 110 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
    • 组织特异性Highly expressed in proliferating cells.
    • 序列相似性Belongs to the XPO2/CSE1 family.
      Contains 1 importin N-terminal domain.
    • 细胞定位Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CAS antibody
      • Cellular apoptosis susceptibility protein antibody
      • Chromosome segregation 1 (yeast homolog) like antibody
      • Chromosome segregation 1 Like antibody
      • Chromosome segregation 1 like protein antibody
      • Chromosome segregation 1-like protein antibody
      • Chromosome segregation gene CSE1 antibody
      • CSE 1 antibody
      • CSE 1 chromosome segregation 1 like antibody
      • CSE 1 chromosome segregation 1 like protein antibody
      • CSE 1L antibody
      • CSE1 antibody
      • CSE1 chromosome segregation 1 like (yeast) antibody
      • CSE1 chromosome segregation 1 like antibody
      • CSE1 chromosome segregation 1 like protein antibody
      • CSE1L antibody
      • Exp 2 antibody
      • Exp2 antibody
      • Exportin 2 antibody
      • Exportin-2 antibody
      • Exportin2 antibody
      • Importin alpha re exporter antibody
      • Importin-alpha re-exporter antibody
      • MGC117283 antibody
      • MGC130036 antibody
      • MGC130037 antibody
      • XPO 2 antibody
      • XPO2 antibody
      • XPO2_HUMAN antibody
      see all

    Anti-Cellular Apoptosis Susceptibility antibody 图像

    • Ab27518, at a dilution of 1/100, staining Cellular Apoptosis Susceptibility protein in formalin fixed paraffin embedded human liver carcinoma tissue section by Immunohistochemistry.

    Anti-Cellular Apoptosis Susceptibility antibody (ab27518)参考文献

    This product has been referenced in:
    • Pupure J  et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett 470:100-5 (2010). WB, IHC-P ; Mouse . Read more (PubMed: 20036318) »
    • Wang Y  et al. Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Mol Cell Proteomics 8:585-95 (2009). Read more (PubMed: 19001410) »

    See all 2 Publications for this product

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