Potent β-lactam antibiotic. Effective against Gram-positive and Gram-negative bacteria. Neuroprotective effects in vivo.
(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt hemi(heptahydrate)
Store at +4°C. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wei J et al. The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury. J Trauma Acute Care Surg73:654-60 (2012).
Read more (PubMed: 22710775) »
Gunduz O et al. Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the ß-lactam antibiotic, ceftriaxone, in mice. Pharmacol Biochem Behav99:100-3 (2011).
Read more (PubMed: 21536061) »