Ceefourin™ 2,MRP4抑制剂(ab145145)
Key features and details
- Highly selective multidrug resistance protein 4 (MRP4) inhibitor
- CAS Number: 348148-51-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Ceefourin™ 2,MRP4抑制剂 -
描述
Highly selective multidrug resistance蛋白4 (MRP4)抑制剂 -
生物学描述
Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 in vitro. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).
-
纯度
> 98% -
常规说明
Sold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute. -
CAS编号
348148-51-6 -
化学结构
性能
-
化学名称
3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid -
分子量
355.70 -
分子式
C15H9ClF3N3O2 -
PubChem识别号
1366977 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
FC(F)(F)c1cc(nc2c(Cl)c(nn12)C(=O)O)c3ccc(C)cc3 -
来源
Synthetic
-
研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab145145 尚未被引用在任何文献中。