概述

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris-saline. pH 7.3
  • Concentration information loading...
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab2751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明Tested in peptide ELISA at 1:64000.
    IHC-P: Use at a concentration of 5 µg/ml.
    Western Blot: Preliminary experiments gave an approx 35kDa band in K562 lysates at 1µg/ml. However, this was accompanied by stronger bands at approx 45kDa and 48kDa. Please note that currently we cannot find an explanation in the literature for these extra bands given the predicted size of approx. 35kDda according to NP_057399.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
    • 组织特异性Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
    • 序列相似性Belongs to the ced-6 family.
      Contains 1 PID domain.
    • 细胞定位Cytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CED6 antibody
      • Cell death protein 6 homolog antibody
      • Engulfment adapter protein antibody
      • Engulfment adaptor PTB domain containing 1 antibody
      • GULP antibody
      • GULP, engulfment adaptor PTB domain containing 1 antibody
      • GULP1 antibody
      • GULP1_HUMAN antibody
      • Protein GULP antibody
      • PTB domain adapter protein CED 6 antibody
      • PTB domain adapter protein CED-6 antibody
      • PTB domain adaptor protein CED6 antibody
      • PTB domain-containing engulfment adapter protein 1 antibody
      see all

    Anti-CED6 antibody 图像

    • ab2751 at 5ug/ml staining CED6 in human kidney tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). The AP-staining procedure was used for detection.

    Anti-CED6 antibody (ab2751)参考文献

    ab2751 has not yet been referenced specifically in any publications.

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