CDPPB,positive allosteric modulator for mGlu5 (ab120363)
Key features and details
- PAM for mGlu5. Active in vivo.
- CAS Number: 781652-57-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
CDPPB,positive allosteric modulator for mGlu5 -
描述
PAM for mGlu5. Active in vivo. -
生物学描述
Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic in vivo.
-
CAS编号
781652-57-1 -
化学结构
性能
-
化学名称
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide -
分子量
364.41 -
分子式
C23H16N4O -
PubChem识别号
11245456 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
N#Cc1cccc(c1)C(=O)Nc3cc(nn3c2ccccc2)c4ccccc4 -
来源
Synthetic
-
研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab120363 尚未被引用在任何文献中。